Local reproductive tract immunity to sperm-specific lactate dehydrogenase-C4
نویسندگان
چکیده
منابع مشابه
Characterization of monoclonal antibodies to the sperm-specific lactate dehydrogenase isozyme.
The isozyme of lactate dehydrogenase (LDH) that is specific to testes, designated LDH-C4, is the predominant LDH isozyme in mammalian spermatozoa. Four high-affinity monoclonal antibodies have been developed to murine LDH-C4. These antibodies were tested for crossreactivity with LDH-C4 from rat, hamster, rabbit, and human by competitive binding radioimmunoassays. Monoclonal antibodies RG-1 and ...
متن کاملSperm transport in the female reproductive tract.
At coitus, human sperm are deposited into the anterior vagina, where, to avoid vaginal acid and immune responses, they quickly contact cervical mucus and enter the cervix. Cervical mucus filters out sperm with poor morphology and motility and as such only a minority of ejaculated sperm actually enter the cervix. In the uterus, muscular contractions may enhance passage of sperm through the uteri...
متن کاملSperm Transport in the Mare Reproductive Tract: A Review
The objective of this study was to review the literature on sperm transport in the mare. During this process the sperm cells must reach the oviducts in order to fertilize the oocyte, but before reaching this site it must go through the uterus that is a hostile environment at this moment since there is an inflammatory reaction in this location that aims to eliminate excess spermatozoa and bacter...
متن کاملA further study of human seminal plasma lactate dehydrogenase-C4 (LDH-C4): kinetic properties of LDH-C4.
Lactate dehydrogenase-C4 (LDH-C4) from human seminal plasma was purified by 40-60% (NH4)2SO4 precipitation, Oxamate-Sepharose 4B affinity column chromatography and AMP affinity column chromatography. Enzyme kinetic studies of human seminal plasma LDH-C4 were performed with purified LDH -C4. The human LDH-C4 exhibits a much higher affinity for pyruvate and alpha-ketovalerate than lactate. Appare...
متن کامل1856 Suppressor Factor Specific for Lactate Dehydrogenase
Antigen-specific, T cell-derived factors have been the subject of extensive studies as possible mediators of immunoregulatory interactions (reviewed in references 1-3). Functionally, two kinds of factor, helper and suppressor, can be distinguished. The suppressor factors (TsF), x again, fall into two categories, namely, inducer factors (TsiF) that play a role in communication between T cell set...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1986
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod35.4.873